Official diplomatic relations between the Philippines and Brazil were deemed to have been established upon the recognition of Philippine Independence in July 1946.

During the inaugural ceremony on 04 July 1946, the Brazilian Government sent Hon. Carlos Silverio Martins Ramos, Special Representative of President Eurico Gaspar Dutra. This marked the official recognition of the Philippines as a sovereign state of Brazil.

The Philippine Embassy in Washington initially exercised jurisdiction over Brazil, which was later transferred to the Philippine Embassy in Argentina upon the opening of the Philippine representation in Buenos Aires.

On 16 September 1965, Ambassador Carlos S. Tan opened the first Philippine Embassy in Rio de Janeiro, the former capital of Brazil and where most embassies were located during that time. To encourage embassies to relocate from Rio de Janeiro to the new administrative capital of Brasilia, the Brazilian Government offered to donate land for free to diplomatic missions.

On 01 September 1973, the mission transferred to Brasilia on a piece of property located at the corner of the northern embassy sector (Setor Embaixada Norte) with a land area of 2.5 hectares.